RxFiles Lipids

Dyslipidemia Newsletter - Winter 2024/2025

The Dyslipidemia Newsletter covers cardiovascular risk assessment, statin intolerance, the evidence for ezetimibe, the management of high triglycerides, and FAQs on the management of dyslipidemia.

Lipid Lowering Therapy Drug Comparison Chart

The Lipid Lowering Therapy Charts cover an approach to treating dyslipidemia in both primary and secondary prevention and compare statin and non-statin medication options.

Lipid Landmark Trials

An overview of landmark trials for statins and non-statin medications and their effect on all-cause mortality and cardiovascular outcomes.

Dyslipidemia - Frequently Asked Questions

Thirteen frequently asked questions covering the management of dyslipidemia, the nuances of statin treatment, muscle-related statin intolerance, and other statin-related adverse events.

Management Considerations for Statin Intolerance

A Q&A summary for the management of patients with myopathies.

Deciding if a statin is right for you

A 2-page patient guide to help individuals understand the possible benefits of statin therapy to aid in making informed decisions about their use for managing cholesterol and preventing cardiovascular disease. This resource also addresses common statin myths.

Rumour has it that statins cause muscle aches, but do they really?

A 2-page patient tool that explores the evidence behind the common belief that statins cause muscle aches, providing a balanced view of the actual risks and benefits of statin use. This resource also discusses how statin-related muscle aches can be managed.

Physical Activity Prescription

The Physical Activity Prescription highlights the importance of regular exercise, offering practical examples and guidelines to help patients and healthcare professionals work together to integrate exercise into daily routines. This resource provides valuable tips and recommendations for both aerobic and strength activities, designed to help individuals gradually enhance their physical function and overall health. It also underscores the numerous health benefits of physical activity, including reducing the risk of chronic diseases, improving quality of life, and managing pain.

Also available in French: https://www.rxfiles.ca/RxFiles/uploads/documents/Exercise-RxFiles-French.pdf

LODESTAR Trial Summary

The LODESTAR Trial examines treat-to-target versus high-intensity statins in patients with coronary artery disease.

REPRIEVE Trial Summary

The REPRIEVE Trial examines pitavastatin to prevent cardiovascular disease in HIV infection.

REDUCE-IT Trial Summary

The REDUCE-IT Trial examines cardiovascular outcomes for icosapent ethyl (VASCEPA) versus mineral oil as placebo in patients with elevated triglyceride levels despite statin therapy.

FOURIER Trial Summary

The FOURIER Trial examines evolocumab (REPATHA) and clinical outcomes in patients with cardiovascular disease.

ODYSSEY Trial Summary

The ODYSSEY Trial evaluates the efficacy of alirocumab, a PCSK9 inhibitor, in reducing cardiovascular events in patients who had experienced an acute coronary syndrome within the past 1 to 12 months and were already on maximally tolerated statin therapy.

RxFiles: Lipids